Xiaowei Wu

Assistant Professor

Department of Statistics

Virginia Polytechnic Institute and State University


Office: Hutcheson Hall 212

Phone: (540)231-0023

Email: xwwu@vt.edu





Rice University, Houston, TX




Electrical Engineering

Wuhan University, Wuhan, China




Electrical Engineering

Wuhan University, Wuhan, China



Academic Employment

Assistant Professor

Virginia Polytechnic Institute and State University

2012 --


Postdoctoral Scholar

The University of Chicago

2010 -- 2012


Research Interests

Statistical Genetics, Bioinformatics, Bayesian and Computational Statistics, Branching Processes


Recent Publications

Peer Reviewed

-- Wu, X., Guan, T., Liu, J.D., Leon-Novelo, L.G. and Bandyopadhyay, D. (2018). Adaptive-weight burden test for associations between quantitative traits and genotype data with complex correlations. The Annals of Applied Statistics, 12(3): 1558--1582, doi: 10.1214/17-AOAS1121.

-- Wu, X. (2018). Borrowing strength from complex genotypic correlations: multiple genetic variant association testing for quantitative traits. Book chapter accepted. Contemporary Biostatistics with Biopharmaceutical Application.

-- Wu, X. and McPeek, M.S. (2018). L-GATOR: Genetic association testing for a longitudinally-measured quantitative trait in samples with related individuals. The American Journal of Human Genetics, 102:574--591, doi: 10.1016/j.ajhg.2018.02.016.

-- Luo, Y., He, J., Xu, X., Sun, M., Wu, X., Lu, X. and Xie, H. (2018). Integrative single-cell omics analyses reveal epigenetic heterogeneity in mouse embryonic stem cells. PLoS Computational Biology, 14(3): e1006034, doi: 10.1371/journal.pcbi.1006034.

-- Rodrigues, R., Rodgers, N., Wu, X. and Williams, M. (2018). COREMIC: a web-tool to search for a niche associated CORE MICrobiome. PeerJ, 6:e4395 https://doi.org/10.7717/peerj.4395.

-- Tran, H., Zhu, H., Wu, X., Kim, G., Clarke, C.R., Larose, H., Haak, D.C., Askew, S.D., Barney, J.N., Westwood, J.H. and Zhang, L. (2018). Identification of differentially methylated sites with weak methylation effect. Genes, 9(2), 75.

-- Hasan, M. S., Wu, X., Watson, L. T. and Zhang, L. (2017). UPS-indel: a universal positioning system for indels. Scientific Reports, 7(1):14106.

-- Jin, X., Xiang, X., Guan, X., Bai, Q., Wu, X. and Zhou, Y. (2017). Assessing the relationship between the spatial distribution of land consolidation projects and of farmland resources in China, 2006-2012. Food Security, 9(5):889--905.

-- Zhu, H., Casters, P., Morris, J.S., Wu, X. and Mueller, R. (2017). A unified analysis of structured sonar-terrain data using Bayesian functional mixed models. Technometrics, 60(1):112--123, doi:10.1080/00401706.2016.1274681.

-- Leon-Novelo, L.G., Womack, A., Zhu, H. and Wu, X. (2017). A Bayesian analysis of bioassay experiments. Statistics in Medicine, 36(12):1907--1923.

-- Zhang, S., Wu, X. and You, Z. (2017). Jaccard distance based weighted sparse representation for coarse-to-fine plant species recognition. PLoS One, 12(6):e0178317.

-- Zhang, S., Zhu, Y., You, Z. and Wu, X. (2017). Fusion of superpixel, expectation maximization and PHOG for recognizing cucumber diseases. Computers and Electronics in Agriculture, 140:338--347.

-- Zhang, S., You, Z. and Wu, X. (2017). Plant disease leaf image segmentation based on superpixel clustering and EM algorithm. Neural Computing and Applications, doi:10.1007/s00521-017-3067-8.

-- Zhang, S., Wu, X., You, Z. and Zhang, L. (2017). Leaf image based cucumber disease recognition using sparse representation classification. Computers and Electronics in Agriculture, 134:135--141.

-- Wang, Z., Xu, K., Zhang, X., Wu, X. and Wang, Z. (2017). Longitudinal SNP-set association analysis of quantitative phenotypes. Genetic Epidemiology, 41(1):81--93. DOI: 10.1002/gepi.22016.

-- Sun, M., Sun, Z., Wu, X., Rajaram, V., Keimig, D., Lim, J., Zhu, H. and Xie, H. (2016). Mammalian brain development is accompanied by a dramatic increase in cell-subset specific DNA methylation. Scientific Reports, 6:32298.

-- Jin, X., Zhang, Z., Wu, X., Xiang, X., Sun, W., Bai, Q. and Zhou, Y. (2016). Co-ordination of land exploitation, exploitable farmland reserves and national planning in China. Land Use Policy, 57, 682--693.

-- Tran, H., Wu, X., Tithi, S., Sun, M., Xie,H. and Zhang, L. (2016). A Bayesian assignment method for ambiguous bisulfite short reads. PLoS One, 11(3):e0151826.

-- Wu, X. and Zhu, H. (2015). A Bayesian analysis of copy number variations in array comparative genomic hybridization data. International Journal of Biomedical Data Mining, 4:116.

-- Hasan, M. S., Wu, X. and Zhang, L. (2015). Performance evaluation of indel calling tools using real short-read data. Human Genomics, 9:20.

-- Karunasena, E., McIver, L.J., Bavarva, J.H., Wu, X., Zhu, H., Garner, H.R. (2015). 'Cut from the same cloth': Shared microsatellite variants among cancers link to ectodermal tissues-neural tube and crest cells. Oncotarget, 6(26):22038--22047.

-- Wu, X., Sun, M., Zhu, H. and Xie, H. (2015). Nonparametric Bayesian clustering to detect bipolar methylated genomic loci. BMC Bioinformatics, 16:11.

-- Wu, X. and Zhu, H. (2015). Fast maximum likelihood estimation of mutation rates using a birth-death process. Journal of Theoretical Biology, 366:1-7.

-- Karunasena, E., McIver, L.J., Rood, B.R., Wu, X., Zhu, H., Bavarva, J.H. and Garner, H.R. (2014). Somatic microsatellite loci differentiate glioblastoma from lower-grade gliomas. Oncotarget, 5(15) 6003-6014.

-- Li, Z., Wu, X.#, He, B. and Zhang, L. (2014). Vindel: a simple pipeline for checking indel redundancy. BMC Bioinformatics, 15:359.                               # co-first author

-- Wu, X. and Kimmel, M. (2013). Modeling neutral evolution using an infinite-allele Markov branching process. International Journal of Stochastic Analysis, Volume 2013 (2013), Article ID 963831.

-- Wu, X. and Kimmel, M. (2010). A note on the path to extinction of critical Markov branching processes. Statistics & Probability Letters, 80, 263-269.

-- Wu, X., Strome, E. D., Meng, Q., Hastings, P. J., Plon, S. E. and Kimmel, M. (2009). A robust estimator of mutation rates. Mutation Research, 661, 101-109.

-- Strome, E. D., Wu, X., Kimmel, M. and Plon, S. E. (2008). Heterozygous screen in Saccharomyces Cerevisiae identifies dosage-sensitive genes that affect chromosome stability. Genetics, 178, 1193-1207.



Conference Proceedings

-- Banerjee, S., Chen, X., Wu, X., Xie, H., Xuan, J. and Feng, W-C. (2017). ChIP-GMM: A Gaussian mixture model for inferring binding regions in ChIP-seq profiles. The 9h International Conference on Bioinformatics and Computational Biology.

-- Hasan, M. S., Wu, X., Watson, L. T., Li, Z. and Zhang, L. (2016). UPS-indel: A better approach for finding indel redundancy. IEEE 6th International Conference on Computational Advances in Bio and Medical Sciences.

-- Tran, H., Wu, X. and Zhang, L. (2015). A Bayesian method for assigning ambiguous bisulfite short reads. The 7th International Conference on Bioinformatics and Computational Biology.

-- Zhu, H., Wu, X., Xu, X. and Wu, C. (2007). Feature extraction and categorization of patient respiration pattern in radiation therapy. The 15th International Conference on the Use of Computers in Radiation Therapy Proceedings.

-- Wu, X., Chan, Y., Preissl, H., Eswaran, H., Wilson, J., Murphy, P. and Lowery, C. L. (2004). Time-frequency and coherence analysis of FMEG signals. The 14th International Conference on Biomagnetism Proceedings.



STAT4094 Introduction to R Programming: spring 2016, 2017, 2018

STAT4714 Probability and Statistics for Electrical Engineers: fall 2012, 2013

STAT4984/5984G Statistical Genomics: spring 2013

STAT4364/5364G Introduction to Statistical Genomics: spring 2014, fall 2018

STAT5034 Inference Fundamentals: fall 2014, 2015, 2016

STAT5434 Applied Stochastic Processes: spring 2015, 2016, 2017, 2018